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Rather than directly correcting pigmentation at its source, certain ingredients may influence oxidative pathways and melanin regulation processes within the body
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Oxidative stress, inflammation and accelerated ageing are accompanied by damage to the central nervous system, including neurodegeneration
In contrast, severe vitamin E deficiency might be caused by disease such as lipid absorption abnormalities or polymorphisms in the liver-associated TTP resulting in reduced plasma levels, manifesting in, for example, acute peripheral neuropathy (degeneration of large calibre axons in sensory neurons), pigmented retinopathy, skeleton myopathy, spinocerebellar ataxia and immune system impairment, the progression of which can be decelerated and potentially reversed by tocopherol supplementation [133, 251, 298, 299]
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